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Protocol 01 longevity supplement powder mixed in a glass · Essense
Protocol 01
Protocol 01
Protocol 01
Protocol 01
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Cellular Health · Powder Formula

Protocol 01

NR · Lion's Mane · CoQ10 · Resveratrol · 31 Actives

★★★★★ 4.9 · 312 Reviews
31 Active IngredientsClinically Dosed30 Sachets100% VeganThird-Party Tested
↑ Natural energy boost, without stimulants or crashes
↑ Cellular repair, activates longevity sirtuins and DNA repair pathways
↑ Sharper focus, and mental clarity from replenished NAD+ stores
↑ Healthier ageing, supports mitochondrial function and metabolic health
↑ No fillers, no synthetic additives, pure active ingredients only

Contents: 30 single-serve sachets · 378g powder · 12.6g per serving · Coconut flavour

"NR is the most researched longevity compound of the last decade. The dosing in Protocol 01 is clinically meaningful and bioavailability-optimised."

Dr. Sarah Mitchell, PhD, Longevity & Cellular Biology

£57 / month £79SAVE 28%

90-day supply · £171 billed every 3 months · all essentials day one

Flavour: Coconut

30 single-serve sachets per pack, pre-portioned for perfect dosing on the go.

Pre-order · Ships October 2026

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What's Inside

12.6g per serving · 30 servings · 378g total

Structural Foundation

  • L-Creatine Monohydrate: 3000mg
  • L-Glycine: 2000mg
  • Trisodium Citrate: 1850mg
  • Betaine Anhydrous: 1000mg
  • Glucosamine Sulphate 2KCL: 1000mg
  • Calcium Carbonate: 660mg
  • Aquamin® Calcium Citrate Malate: 385mg
  • Potassium Chloride: 380mg

Brain & Cognitive Health

  • Lion's Mane Extract 5:1: 250mg
  • Ginkgo Biloba Extract 10:1: 200mg
  • Alpha Lipoic Acid: 200mg

Longevity & Cellular Health

  • Japanese Knotweed Root Extract (100mg Resveratrol): 200mg
  • Nicotinamide Riboside Chloride (NR): 200mg
  • Sophora Japonica Extract (180.5mg Quercetin): 190mg
  • Magnesium Malate: 185mg
  • Magnesium Taurate: 107mg
  • Coenzyme Q10: 100mg
  • Sodium Hyaluronate (97mg Hyaluronic Acid): 100mg
  • Astaxanthin Powder: 2.4mg

Vitamins & Minerals

  • Vitamin B3 (Nicotinamide): 94.3mg · 589% NRV
  • Vitamin C (L-Ascorbic Acid): 79.8mg · 100% NRV
  • Zinc Bisglycinate: 37.5mg · 75% NRV
  • Vitamin D3 (Cholecalciferol): 10mcg · 200% NRV
  • Vitamin B7 (D-Biotin): 2mg · 80% NRV
  • Vitamin B6 (Pyridoxine HCl): 1.4mg · 100% NRV
  • Vitamin B1 (Thiamine HCl): 1.1mg · 100% NRV
  • Chromium Picolinate: 240mcg · 60% NRV
  • Vitamin B12 (Methylcobalamin): 200mcg · 80% NRV
  • Vitamin K2 (MK-7): 52mcg · 69% NRV
  • L-5-Methyltetrahydrofolate Calcium: 180mcg · 72% NRV
  • Selenium (from Selenomethionine): 42mcg · 76% NRV
How to Use

Tear open one sachet and mix with 200ml of cold water or juice. Take each morning, with or without food. Do not mix with hot liquids to preserve ingredient integrity.

The Science

NAD+ is essential for energy metabolism, DNA repair and sirtuin activation, proteins that regulate cellular ageing. NAD+ declines ~50% between ages 40 and 60. NR is its most bioavailable precursor, supported by multiple human clinical trials on healthy ageing.

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31+
active ingredients in every serving, clinically dosed with no fillers
Full Label
12.6g
per serving. A complete daily formula in a single morning scoop
One Ritual
4.9★
average rating across 312 verified reviews
Verified Purchases
0
proprietary blends, synthetic fillers or hidden doses. Everything on the label
Transparency Standard
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Formulated as One System

The Philosophy

Engineered as one.

Most stacks are a shelf of single bottles fighting for attention. Protocol 01 was formulated as one system: each dose calibrated to work with the next, from NR and resveratrol to creatine and electrolytes.

01
Clinically dosedEvery active at the level the studies actually used, printed on the label.
02
One ritual, not tenA single morning scoop replaces a drawer full of capsules.
03
Tested, then tested againEvery batch verified by accredited third-party labs for purity and potency.

The Ingredients

Full Label →
200mg
NR (Nicotinamide Riboside)
The most bioavailable NAD+ precursor. Replenishes cellular energy and activates longevity sirtuins. NAD+ declines ~50% between ages 40 and 60.
Longevity
250mg
Lion's Mane Extract
5:1 concentrated extract. Stimulates nerve growth factor (NGF) synthesis, supporting memory, focus and long-term neuroplasticity.
Brain Health
100mg
Coenzyme Q10
Essential cofactor in the mitochondrial electron transport chain. Supports cellular energy production and acts as a potent lipid-soluble antioxidant.
Mitochondria
100mg
Trans-Resveratrol
Polyphenol sirtuin activator from Japanese Knotweed Root Extract. Works synergistically with NR to enhance longevity pathway signalling.
Sirtuin Activator

How it works

01
Mix one scoop
One sachet into 200ml of cold water, juice or your morning smoothie. Takes 10 seconds. Best taken first thing in the morning.
02
Absorb & activate
Powder format delivers superior bioavailability vs capsules. NR reaches your cells faster and begins replenishing NAD+ within hours of your first serving.
03
Feel the difference
Most members notice improved energy and mental clarity within 2–4 weeks. By month 3, the difference in recovery, sleep quality and skin is measurable.

One scoop vs a shelf of pills.

Rebuilding Protocol 01 from single products means four subscriptions, a cabinet of bottles and a handful of capsules every morning.

Building this stack yourself
Nicotinamide Riboside 200mgQuality NR, third-party tested
£42/mo
Lion's Mane + Ginkgo stackConcentrated extracts, properly dosed
£19/mo
CoQ10 + Trans-ResveratrolBioavailable forms at clinical doses
£26/mo
Creatine, magnesium + electrolytesThe structural foundation, bought separately
£28/mo
Bought separately £115+

Typical UK retail for quality single-ingredient supplements, per month.

Protocol 01 · All of it, in one scoop
£57 / month

On the 3-Month Plan. £68/month on the monthly subscription, £79 one-time.

Half the price of building it yourself

The Ritual

The morning decides the day.

200ml of cold water, one scoop, ten seconds. The simplest habit in your routine, and the one everything else builds on.

Protocol 01 · Daily

What to expect.

Longevity work compounds. Give it the 90 days it deserves.

01 Weeks 2–4

Energy settles in

A steadier baseline replaces the caffeine rollercoaster: consistent energy through the afternoon and sharper focus in the morning.

02 Weeks 4–8

Visible on the outside

Skin, hair and sleep quality typically respond next. The hyaluronic acid, biotin and mineral stack works quietly while the NAD+ pathway does the deep work.

03 Month 3

Measurable change

Recovery, sleep and skin become noticeably different, and NAD+ level increases become measurable. This is why we recommend a 90-day commitment.

Individual results and timing vary.

Is it for you?

Protocol 01 is for you if…
✓ You want one clean daily foundation instead of a shelf of separate pills.
✓ You train, work hard and want energy without living on caffeine.
✓ You read labels and want every dose visible, with nothing hidden in a blend.
✓ You're building habits now that your future self will thank you for.
It's probably not for you if…
× You expect results overnight. This is a 90-day commitment, not a quick fix.
× You want the cheapest capsules on the market. Clinical doses cost more to make.
× You're pregnant, breastfeeding or under 18. Speak to a healthcare professional first.

Food supplements are not a substitute for a varied, balanced diet and a healthy lifestyle.

What's in the box

Always included

30 Single-Serve Sachets

Pre-portioned for perfect dosing on the go, no scoops, no mess. Each box contains a 30-day supply.

Monthly3-MonthOne-Time

Day one with the 3-month plan

Metal Jar

Brushed steel storage jar for your sachets. Engraved with the Essense mark, a ritual object built to last.

3-Month Ritual

Month 1 with monthly · Day one with 3-month

Glass Water Bottle

500ml borosilicate glass with brushed steel cap. BPA-free, temperature-neutral, engraved with the Essense mark.

Monthly → month 13-Month Ritual

The ritual, daily.

Where Protocol 01 lives: the kitchen counter at 07:00, the shelf it cleared, and everywhere you take it.

essense
07:00 · The Scoop
200ml of cold water, one sachet, ten seconds. Done before the coffee brews.
essense
The Shelf
One box replaces the supplement drawer. 31 actives, zero clutter.
essense
On the Go
Pre-portioned sachets travel from studio bag to carry-on without a second thought.

Customer Reviews

4.9
★★★★★

312 verified reviews

★★★★★

Three months in and my energy is different. Not caffeine energy, a deep, consistent baseline. My partner noticed before I did.

Amelia R.
Monthly Ritual · 3 months
★★★★★

I'm a functional medicine doctor. The stack is exactly what I'd formulate. Powder format means superior bioavailability. Genuinely impressive.

Dr. Sarah M.
Three-Month Ritual · Verified
★★★★★

The scoop and bottle make this a proper ritual. I look forward to my morning mix every day. Four months with no intention of stopping.

Lena K.
Monthly Ritual · 4 months